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SKLB1002 is a potent and ATP-competitive VEGFR2 inhibitor with IC50 of 32 nM.
| Cell Experiment | |
|---|---|
| Cell lines | HUVECs, L-02, B16-F10, HepG2, and SW620 cells. |
| Preparation method | Cell proliferation Using MTT assay to measure cell proliferation . Various cells including HUVECs, L-02, B16-F10, HepG2, and SW620 are treated with indicated concentrations of SKLB1002 for 24 hours. Vandetanib and sunitinib serve as positive controls. Each assay is replicated 3 times. |
| Concentrations | ~40 μM |
| Incubation time | 24 hours |
| Animal Experiment | |
|---|---|
| Animal models | Mice bearing SW620 or HepG2 tumors |
| Formulation | 35% (v/v) polyethylene glycol solution containing 5% (v/v) DMSO |
| Dosages | ~100 mg/kg daily |
| Administration | i.p. |
| Molecular Weight | 320.39 |
| Formula | C13H12N4O2S2 |
| CAS Number | 1225451-84-2 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Wen Nie, et al. Synergic antitumor effect of SKLB1002 and local hyperthermia in 4T1 and CT26
| Related VEGFR/PDGFR Products |
|---|
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ABT-869 (Linifanib) is an ATP-competitive, multi-targeted RTK inhibitor that is completely effective against all members of VEGFR and PDGFR. |
| Tivozanib (AV-951)
Tivozanib (AV-951) is a potent VEGFR-1, 2 and 3, c-Kit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM respectively. |
| Axitinib
Axitinib (AG013736) inhibits multiple targets including VEGFR, PDGFR and cKit. |
| Regorafenib
Regorafenib (BAY 73-4506) is a novel oral multikinase inhibitor of c-KIT, VEGFR2, B-Raf with IC50s of 17, 40 and 69 nM respectively. |
| Nintedanib
Nintedanib (BIBF1120) is a novel, potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. |
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