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SKLB-23bb

Cat. No. M20637

All AbMole products are for research use only, cannot be used for human consumption.

SKLB-23bb Structure

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Quality Control & Documentation
Biological Activity

SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.

Chemical Information
Molecular Weight 396.44
Formula C21H24N4O4
CAS Number 1815580-06-3
Solubility (25°C) DMSO 79 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wanhua Zhang, et al. Bioorg Chem. SKLB-14b, a novel oral microtubule-destabilizing agent based on hydroxamic acid with potent anti-tumor and anti-multidrug resistance activities

[2] Linyu Yang, et al. J Med Chem. Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity

[3] Fang Wang, et al. Mol Cancer Ther. SKLB-23bb, A HDAC6-Selective Inhibitor, Exhibits Superior and Broad-Spectrum Antitumor Activity via Additionally Targeting Microtubules

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  Catalog
Abmole Inhibitor Catalog




Keywords: SKLB-23bb supplier, HDAC, inhibitors, activators

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