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SKI II is a highly selective and oral active inhibitor of sphingosine kinase (SK) activity, with IC50 values of 78 μM and 45 μM for SK1 and for SK2, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2.
| Cell Experiment | |
|---|---|
| Cell lines | T-24, MCF-7, MCF-7/VP, NCI/ADR cell lines |
| Preparation method | T24, MCF-7, MCF-7/VP, and NCI/ADR cells are plated into 96-well tissue culture plates at ~15% confluency. 24 hours Later, treating the cells are with various concentrations of inhibitors. An additional 48 hours later , cell survival is assayed using the sulforhodamine B assay |
| Concentrations | ~50 μM |
| Incubation time | 48 hours |
| Animal Experiment | |
|---|---|
| Animal models | JC xenografts are established in mice |
| Formulation | DMSO (ip), polyethylene glycol 400 (oral) |
| Dosages | ~100 mg/kg |
| Administration | Intraperitoneal administration or oral administration |
| Molecular Weight | 302.78 |
| Formula | C15H11ClN2OS |
| CAS Number | 312636-16-1 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Michael Hasler, et al. On the measurement of ski boot viscoelasticity
[5] Ying Liu, et al. SKI-II reverses the chemoresistance of SGC7901/DDP gastric cancer cells
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