All AbMole products are for research use only, cannot be used for human consumption.
Sitravatinib (MGCD516) is an orally active receptor tyrosine kinase (RTK) inhibitor. Inhibition of Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, and TRKB at 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, respectively. 29 nM, 5 nM and 9 nM. Sitravatinib alone has a potent antitumor effect and enhances pD-1 blockade activity by promoting the antitumor immune microenvironment.
Mol Cell Proteomics. 2024 Mar 28;23(5):100756.
Dynamic proteomic changes in tumor and immune organs reveal systemic immune response to tumor development
Sitravatinib purchased from AbMole
| Molecular Weight | 629.68 |
| Formula | C33H29F2N5O4S |
| CAS Number | 1123837-84-2 |
| Solubility (25°C) | DMSO ≥ 26 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Products are for research use only. Not for human use. We do not sell to patients.
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