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Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure. IC50 value: Target: ETA receptor
| Molecular Weight | 454.9 |
| Formula | C18H15ClN2O6S2 |
| CAS Number | 184036-34-8 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[1] Iain M MacIntyre, et al. Drugs Today (Barc). Sitaxsentan sodium for pulmonary hypertension
[3] Eric T Wittbrodt, et al. Ann Pharmacother. Sitaxsentan for treatment of pulmonary hypertension
| Related Endothelin Receptor Products |
|---|
| Zibotentan
Zibotentan (ZD4054) is a more selective and specific endothelin-A receptor (ETAR) antagonist with an IC50 value of 21 nM. |
| Ambrisentan
Ambrisentan is an orally active, highly selective antagonist of the endothelin-1 type A receptor. |
| Sitaxsentan sodium
Sitaxsentan (TBC-11251) is an orally active, highly selective antagonist of endothelin A receptors. |
| Macitentan
Macitentan is an orally-active, tissue-targeting dual ET receptor antagonist. |
| Bosentan Hydrate
Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. |
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