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Sitamaquine tosylate

Cat. No. M8569

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Sitamaquine tosylate Structure

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Quality Control & Documentation
Biological Activity

Sitamaquine is an orally active 8-aminoquinoline analog that exhibit antiplasmodial and antileishmanial activities. Sitamaquine accumulates in Leishmania parasites. Sitamaquine potently inhibits respiratory chain complex II (succinate dehydrogenase), which leads to an apoptosis-like death of Leishmania parasites.

Chemical Information
Molecular Weight 515.71
Formula C21H33N3O · C7H8O3S
CAS Number 1019640-33-5
Solubility (25°C) Water: 15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Antonio Casado-Snchez, et al. Effect of electronic and steric properties of 8-substituted quinolines in gold(III) complexes: Synthesis, electrochemistry, stability, interactions and antiproliferative studies

[2] J A Lazaris, et al. Primary insulin insufficiency after blocking of zinc in pancreatic beta-cells

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Keywords: Sitamaquine tosylate supplier, inhibitors, activators

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