All AbMole products are for research use only, cannot be used for human consumption.
SIS3 is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 does not affect the phosphorylation of Smad2.
Cytokine. 2026 Jan 10;199:157113.
IL-6 trans-signaling activates the TGF-β pathway via soluble factors in difficult-to-treat rheumatoid arthritis joint fluid
SIS3 purchased from AbMole
| Molecular Weight | 453.53 |
| Formula | C28H27N3O3 |
| CAS Number | 521985-36-4 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related TGF-beta/Smad Products |
|---|
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Products are for research use only. Not for human use. We do not sell to patients.
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