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Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation. Sinomenine also is an activator of μ-opioid receptor.
Sinomenine (10 to 40 mg/kg) dose-dependently increases the paw withdrawal threshold.
| Molecular Weight | 329.39 |
| Formula | C19H23NO4 |
| CAS Number | 115-53-7 |
| Solubility (25°C) | DMSO 50 mg/mL 1M HCl: 25 mg/mL (ultrasonic and adjust pH to 1 with HCl) |
| Storage | 2-8°C, protect from light |
[2] Wei Jiang, et al. Analgesic Mechanism of Sinomenine against Chronic Pain
[3] Le-Nyu Gao, et al. Mechanism Underlying Antitumor Effects of Sinomenine
| Related NF-κB Products |
|---|
| QNZ
QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel. |
| Caffeic Acid Phenethyl Ester
Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. |
| Cepharanthine
Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. |
| JSH-23
Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| Methylthiouracil
Methylthiouracil is an anti-thyroid agent. Methylthiouracil inhibits TNF-α and IL-6 production and NF-κB and ERK1/2 activation. |
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