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Sinomenine

Cat. No. M14608

All AbMole products are for research use only, cannot be used for human consumption.

Sinomenine Structure
Size Price Availability Quantity
50mg USD 40 In stock
100mg USD 50 In stock
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Quality Control & Documentation
Biological Activity

Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation. Sinomenine also is an activator of μ-opioid receptor.

Sinomenine (10 to 40 mg/kg) dose-dependently increases the paw withdrawal threshold.

Chemical Information
Molecular Weight 329.39
Formula C19H23NO4
CAS Number 115-53-7
Solubility (25°C) DMSO 50 mg/mL
1M HCl: 25 mg/mL (ultrasonic and adjust pH to 1 with HCl)
Storage 2-8°C, protect from light
References

[1] Meng-Wan Zhang, et al. Sinomenine in Cardio-Cerebrovascular Diseases: Potential Therapeutic Effects and Pharmacological Evidences

[2] Wei Jiang, et al. Analgesic Mechanism of Sinomenine against Chronic Pain

[3] Le-Nyu Gao, et al. Mechanism Underlying Antitumor Effects of Sinomenine

[4] Feng Xu, et al. Sinomenine inhibits proliferation, migration, invasion and promotes apoptosis of prostate cancer cells by regulation of miR-23a

[5] Weiwei Liu, et al. Sinomenine Inhibits the Progression of Rheumatoid Arthritis by Regulating the Secretion of Inflammatory Cytokines and Monocyte/Macrophage Subsets

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Keywords: Sinomenine supplier, NF-κB, inhibitors, activators

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