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SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 quarterhydrate inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 quarterhydrate shows no inhibitory activity against cathepsin G.
| Molecular Weight | 544.16 |
| Solubility (25°C) | DMSO 50 mg/mL Ethanol 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cathepsin Products |
|---|
| N-Ethylmaleimide
N-Ethylmaleimide (NEM) is a cysteine protease inhibitor. |
| Odanacatib
Odanacatib (MK-0822) is a potent and reversible covalent inhibitor of CathepsinK (CatK) with an IC50 of 0.2 nM/1 nM for human/rabbit cathepsin B, L, and S and is highly selective. |
| Balicatib
Balicatib is a potent and selective inhibitor of cathepsin K; 10-100-fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S. |
| Aloxistatin
Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor. |
| Cathepsin Inhibitor 1
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
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Products are for research use only. Not for human use. We do not sell to patients.
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