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Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD)
Commun Biol. 2025 Jul 04;8(1):1005.
TopBP1 coordinates DNA repair synthesis in mitosis via recruitment of the nuclease scaffold SLX4
Shield-1 purchased from AbMole
| Molecular Weight | 748.9 |
| Formula | C42H56N2O10 |
| CAS Number | 914805-33-7 |
| Solubility (25°C) | DMSO ≥ 65 mg/mL (ultrasonic and warming) |
| Storage | -20°C, sealed |
| Related FKBP (FK506-binding protein) Products |
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| SAFit2
SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51) with a Ki value of 6 nM. SAfit2 has been used as a potential agent in the study of major depression, obesity, and chronic pain. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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