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Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe is a synthetic thrombin receptor agonist peptide. SFLLRNPNDKYEPF activates and induces platelet aggregation and serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin.
| Molecular Weight | 1739.92 |
| Formula | C81H118N20O23 |
| CAS Number | 137339-65-2 |
| Solubility (25°C) | Water 40 mg/mL DMSO 70 mg/mL |
| Storage | -20°C, dry, sealed |
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