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SF0166 is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. SF0166 inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. SF0166 decreases neovascularization in the oxygen-induced retinopathy mouse model.
| Molecular Weight | 475.49 |
| Formula | C23H27F2N5O4 |
| CAS Number | 1621332-91-9 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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