All AbMole products are for research use only, cannot be used for human consumption.
SEW2871 is a novel, potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. SEW2871 activates S1P1 receptor with an EC50 of 13 nM, but does not activate S1P2, S1P3, S1P4 or S1P5 receptors at concentrations up to 10 μM. SEW2871 is cell-permeable and active in vivo. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses.
| Molecular Weight | 440.36 |
| Formula | C20H10F6N2OS |
| CAS Number | 256414-75-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | Powder -20°C |
[2] Dongdong Zhang, et al. The S1PR1 agonist SEW2871 promotes the survival of skin flap
| Related S1P Receptor Products |
|---|
| FTY720 hydrochloride
Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells. |
| BAF312
BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. |
| CYM-5442
CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 can easily penetrate the central nervous system (CNS). |
| JTE 013
JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM. |
| KRP-203 hydrochloride
Mocravimod (KRP-203) hydrochloride is a potent, orally active sphingosine receptor S1P1 and S1P4 agonist with EC50s of 1 nM and 10 nM, respectively, and may be used in studies related to ulcerative colitis (UC). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
