Free shipping on all orders over $ 500

Setiptiline

Cat. No. M30309

All AbMole products are for research use only, cannot be used for human consumption.

Setiptiline Structure
Synonym:

Org-8282

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.

Chemical Information
Molecular Weight 261.36
Formula C19H19N
CAS Number 57262-94-9
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Michele Protti, et al. Med Res Rev. New-generation, non-SSRI antidepressants: Drug-drug interactions and therapeutic drug monitoring. Part 2: NaSSAs, NRIs, SNDRIs, MASSAs, NDRIs, and others

[2] A Ishii, et al. Leg Med (Tokyo). Sensitive determination of mianserin and setiptiline in body fluids by gas chromatography with surface ionization detection (GC-SID)

[3] H Kodama. Nihon Shinkei Seishin Yakurigaku Zasshi. [Effect of lithium, carbamazepine, and setiptiline on diacylglycerol in rat brain ex vivo]

[4] M Kuniyoshi, et al. Prog Neuropsychopharmacol Biol Psychiatry. Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia

[5] K Yamada, et al. Nihon Yakurigaku Zasshi. [Behavioral effects of a new antidepressant, setiptiline]

Related 5-HT Receptor Products
Granisetron hydrochloride

Granisetron hydrochloride is a potent and selective 5-HT3 receptor antagonist that possesses potent antiemetic activity.
Sumatriptan succinate

Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for the research of migraine headache.
Vortioxetine hydrobromide

Vortioxetine hydrobromide (Lu AA21004) is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist and a 5-HT transporter (5-HTT) inhibitor in vitro.
Prucalopride

Prucalopride is a potent, selective and specific serotonin 5-HT4 receptor agonist with enterokinetic properties.
(1S-cis)-Milnacipran Hydrochloride

(1S-cis)-Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.
  Catalog
Abmole Inhibitor Catalog




Keywords: Setiptiline, Org-8282 supplier, 5-HT Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.