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SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure.
| Molecular Weight | 551.66 |
| Formula | C32H29N3O4S |
| CAS Number | 2139330-34-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 62.5 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Akram Tayanloo-Beik, et al. Front Physiol. Diabetes and Heart Failure: Multi-Omics Approaches
[4] Philip A Bidwell, et al. J Mol Cell Cardiol. HAX-1 regulates SERCA2a oxidation and degradation
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