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Semustine is a methylated derivative of Carmustine and also a DNA alkylating agent, which can form covalent bonds with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand breaks, and DNA-DNA cross-linking, and has antitumor activity.
| Molecular Weight | 247.72 |
| Formula | C10H18ClN3O2 |
| CAS Number | 13909-09-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL Ethanol 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] P E Kintzel. Drug Saf. Anticancer drug-induced kidney disorders
[4] R B Weiss et al. Cancer Treat Rep. Nephrotoxicity of semustine
| Related DNA Alkylator/Crosslinker Products |
|---|
| Apaziquone
Apaziquone is a bioreductive procompound and a chemical analog of the older chemotherapeutic agent mitomycin C. |
| Bendamustine hydrochloride
Bendamustine hydrochloride is a DNA-alkylator with a distinct pattern of activity. |
| Dacarbazine
Dacarbazine (DTIC-Dome; DTIC) is an alkylating agent that acts as a purine nucleotide precursor analog to inhibit purine nucleotide synthesis, thereby inhibiting DNA/RNA Synthesis, and can be used in studies related to melanoma and Hodgkin's lymphoma. |
| Altretamine
Altretamine is an antitumor agent which also acts as a chemosterilant for male houseflies and other insects. |
| Carmustine
Carmustine is an alkylating antineoplastic agent for inhibiting the growth of U87MG glioblastoma cells with IC50 of 1.42 μM. |
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