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Semilicoisoflavone B

Cat. No. M28123

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Semilicoisoflavone B Structure

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Quality Control & Documentation
Biological Activity

Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation.

Chemical Information
Molecular Weight 352.34
Formula C20H16O6
CAS Number 129280-33-7
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic and warming and heat to 60°C)
Storage -20°C, protect from light, dry, sealed
References

[1] Ming-Ju Hsieh, et al. Int J Mol Sci. Semilicoisoflavone B Induces Apoptosis of Oral Cancer Cells by Inducing ROS Production and Downregulating MAPK and Ras/Raf/MEK Signaling

[2] Gaber El-Saber Batiha, et al. Biomolecules. Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae)

[3] Ming-Yao Gu, et al. Mol Nutr Food Res. Licoflavonol Reduces Aβ Secretion by Increasing BACE1 Phosphorylation to Facilitate BACE1 Degradation

[4] Ming-Yao Gu, et al. Mol Nutr Food Res. Glycyrrhiza uralensis and Semilicoisoflavone B Reduce Aβ Secretion by Increasing PPARγ Expression and Inhibiting STAT3 Phosphorylation to Inhibit BACE1 Expression

[5] Qi Wang, et al. J Pharm Biomed Anal. Metabolites identification of bioactive licorice compounds in rats

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