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Selatinib 

Cat. No. M28106

All AbMole products are for research use only, cannot be used for human consumption.

Selatinib  Structure

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Quality Control & Documentation
Biological Activity

Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects.

Chemical Information
Molecular Weight 565.06
Formula C29H26ClFN4O3S
CAS Number 1275595-86-2
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage 4°C, protect from light
References

[1] Meng-Na Wang, et al. Invest New Drugs. First-in-human, phase I single-ascending-dose study of the safety, pharmacokinetics, and relative bioavailability of selatinib, a dual EGFR-ErbB2 inhibitor in healthy subjects

[2] Jin-fang Jiang, et al. Yao Xue Xue Bao. [Metabolic research of domestically developed small molecule tyrosine kinase inhibitors]

[3] Long Zhang, et al. Eur J Med Chem. Discovery of a potent dual EGFR/HER-2 inhibitor L-2 (selatinib) for the treatment of cancer

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  Catalog
Abmole Inhibitor Catalog




Keywords: Selatinib  supplier, EGFR/HER2, inhibitors, activators

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