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Selamectin

Cat. No. M4886

All AbMole products are for research use only, cannot be used for human consumption.

Selamectin Structure
Size Price Availability Quantity
5mg USD 30 In stock
10mg USD 50 In stock
25mg USD 100 In stock
50mg USD 165 In stock
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Quality Control & Documentation
Biological Activity

Selamectin is an antiparasitic agent and insect repellent that activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent filariasis, lymphatic filariasis and nematode infection. Selamectin is also an effective p-glycoprotein substrate and inhibitor with IC50 of 120 nM.

Chemical Information
Molecular Weight 769.96
Formula C43H63NO11
CAS Number 220119-17-5
Form Solid
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jos Manuel Ezquerra-Aznrez, et al. The Veterinary Anti-Parasitic Selamectin Is a Novel Inhibitor of the Mycobacterium tuberculosis DprE1 Enzyme

[2] Mingyang Tang, et al. Ivermectin, a potential anticancer drug derived from an antiparasitic drug

[3] Aleah Pullins, et al. The efficacy of a topical formulation of selamectin plus sarolaner in preventing the development of a macrocyclic lactone-resistant strain of Dirofilaria immitis in cats

[4] Susan Little, et al. Tradition and innovation: Selamectin plus sarolaner. A new tool to control endo- and ectoparasites of cats-Studies from North America and Japan

[5] Maggie A Fisher, et al. A review of the off-label use of selamectin (Stronghold/Revolution) in dogs and cats

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Keywords: Selamectin supplier, Parasite, inhibitors, activators

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