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Sel24-b489 is a novel pan-PIM inhibitor that induces apoptosis in DLBCL cell lines at low/submicromol concentrations and has shown activity in xenotransplantation models. It is an effective oral PIM and FLT3-ITD dual inhibitor with Kds of 2, 2 and 3 nM against PIM1, PIM2 and PIM3, respectively.
| Molecular Weight | 446.14 |
| Formula | C15H18Br2N4O2 |
| CAS Number | 1616359-00-2 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Mei Wu, et al. J Hematol Oncol. FLT3 inhibitors in acute myeloid leukemia
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