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SEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.
| Molecular Weight | 450.6 |
| Formula | C15H18Br2N4.HCl |
| CAS Number | 1609452-30-3 |
| Form | Solid |
| Solubility (25°C) | Water 45 mg/mL DMSO 10 mg/mL (ultrasonic and warming) |
| Storage | 4°C, dry, sealed |
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| R547
R547 is a potent and selective ATP-competitive CDK inhibitor, with Ki values of 2 nM, 3 nM and 1 nM for CDK1/cyclin B, CDK2/cyclin E and CDK4/cyclin D1, respectively. |
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| PD 0332991 HCL
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