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Scrambled 10Panx is the scrambled form of 10Panx (WRQAAFVDSY), a mimetic peptide of pannexin 1 that inhibits dye uptake by macrophages without affecting cellular membrane currents.
| Cell Experiment | |
|---|---|
| Cell lines | MDA-231, and BT-20 cells |
| Preparation method | Exposing cells to various concentrations of 10-Hydroxycamptothecin for 72 hours. Monitoring cell growth by the standard MTT assay. |
| Concentrations | Dissolved in DMSO, final concentrations ~50 μM |
| Incubation time | 72 hours |
| Animal Experiment | |
|---|---|
| Animal models | BALB/c-nu mice transplanted subcutaneously with Colo 205 cells |
| Formulation | Dissolved in propylene glycol |
| Dosages | ~7.5 mg/kg |
| Administration | Orally once per two days |
| Molecular Weight | 1242.37 |
| Formula | C58H79N15O16 |
| CAS Number | 1315378-72-3 |
| Solubility (25°C) | DMSO ≥ 24 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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