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SCH79797

Cat. No. M14050

All AbMole products are for research use only, cannot be used for human consumption.

SCH79797 Structure

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Quality Control & Documentation
Biological Activity

SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes.

Chemical Information
Molecular Weight 371.48
CAS Number 245520-69-8
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] James K Martin 2nd, et al. A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance

[2] Zhao Li, et al. BMX Represses Thrombin-PAR1-Mediated Endothelial Permeability and Vascular Leakage During Early Sepsis

[3] Naveen Gupta, et al. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity

[4] Junhao Yan, et al. Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage

[5] Anatol Manaenko, et al. PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats

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  Catalog
Abmole Inhibitor Catalog




Keywords: SCH79797 supplier, PAR, inhibitors, activators

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