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SCH-23390 maleate

Cat. No. M30773

All AbMole products are for research use only, cannot be used for human consumption.

SCH-23390 maleate Structure
Synonym:

R-(+)-SCH-23390 maleate

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Quality Control & Documentation
Biological Activity

SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM.

Chemical Information
Molecular Weight 403.86
Formula C21H22ClNO5
CAS Number 87134-87-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Pelin Tanyeri, et al. Pharmacol Biochem Behav. Effects of ziprasidone, SCH23390 and SB277011 on spatial memory in the Morris water maze test in naive and MK-801 treated mice

[2] Florence C Heath, et al. Psychopharmacology (Berl). Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning

[3] K Kobayashi, et al. Neuropharmacology. An increase in the in vivo binding of [3H]SCH 23390 induced by MK-801 in the mouse striatum

[4] H Kuribara, et al. Jpn J Pharmacol. SCH 23390 equivalently, but YM-09151-2 differentially reduces the stimulant effects of methamphetamine, MK-801 and ketamine: assessment by discrete shuttle avoidance in mice

[5] J F Marshall, et al. J Neural Transm Gen Sect. Dopamine-glutamate interactions in methamphetamine-induced neurotoxicity

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Keywords: SCH-23390 maleate, R-(+)-SCH-23390 maleate supplier, Dopamine Receptor, inhibitors, activators

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