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SC79 is a specific and BBB permeable Akt activator used to enhance Akt activity. SC79 activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt. SC79 suppresses PHAKTM-GFP plasma membrane translocation, and enhances phosphorylation of all three Akt isoforms in HEK293, HeLa, HL60, NB4, and HsSulton (B cells) cells. SC79 augmentes Akt phosphorylation at both the Thr308 and S473 sites. SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death.
SC79 (0.04 mg/g, i.p.) enables the cytosolic activation of Akt, and recapitulates the primary cellular function of Akt signaling in the permanent focal cerebral ischemia mouse model, resulting in augmented neuronal survival.
*The compound is unstable in solutions, freshly prepared is recommended
NPJ Regen Med. 2025 Jul 23;10(1):35.
Exogenous melatonin alleviates premature ovarian failure by regulating granulosa cell autophagy
SC79 purchased from AbMole
J Ethnopharmacol. 2025 Sep 26; .
Salidroside improves hypoxia-induced milk synthesis disorder and endoplasmic reticulum stress via AKT/mTOR signaling in bovine mammary epithelial cells
SC79 purchased from AbMole
Discov Oncol. 2025 Jun 17;16(1):1129.
RRP9 promotes prostate cancer metastasis and epithelial-mesenchymal transition through activation of the AKT/GSK3β/β-Catenin signaling pathway
SC79 purchased from AbMole
Cell Death Discov. 2024 Aug 29;10(1):389.
CTDSPL2 promotes the progression of non-small lung cancer through PI3K/AKT signaling via JAK1
SC79 purchased from AbMole
Antioxidants (Basel). 2023 Feb 9;12(2):434.
Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway
SC79 purchased from AbMole
J Ethnopharmacol. 2022 Nov 15;298:115637.
Qingfei oral liquid alleviates RSV-induced lung inflammation by promoting fatty-acid-dependent M1/M2 macrophage polarization via the Akt signaling pathway
SC79 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | HsSulton and NB4 cells |
| Preparation method | HsSulton or NB4 cells (2.5 × 105) are plated in a 24-well plate in 500 μL of phenol red-free RPMI medium supplemented with 10% FBS. After incubation for 24 hours, each compound (8 µg/mL) is added and cultured for overnight (16–20 h). Fifty microliters of MTT solution (5 mg/mL in PBS) are added to each well. Following 2 hrs incubation, the purple formazan crystals are dissolved by directly adding in 500 μL of isopropanol with 0.1 M HCl to each well. After clearing the cell debris by centrifugation, the absorbance is measured at a wavelength of 570 nm. |
| Concentrations | 8 μg/mL |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Permanent focal cerebral ischemia mouse model |
| Formulation | - |
| Dosages | 0.04 mg/g |
| Administration | i.p. |
| Molecular Weight | 364.78 |
| Formula | C17H17ClN2O5 |
| CAS Number | 305834-79-1 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Akt Products |
|---|
| AT7867
AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase with an IC50 of 17 nM. |
| GSK690693
GSK690693 is a potent Akt inhibitor (Akt1 IC50 = 2 nM, Akt2 IC50 = 13 nM, Akt3 IC50 = 9 nM) which also inhibited the phosphorylation of the downstream target GSK3b in cells. |
| Perifosine
Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM. |
| MK-2206 2HCl
MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. |
| Ipatasertib
Ipatasertib (GDC-0068, RG7440) is a potent and selective, ATP-competitive Akt inhibitor with IC50 values of 5 to 18 nM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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