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SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors.
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Source | Psychopharmacology (2016). Figure 2. SB742457 |
| Method | i.v. | |
| Cell Lines | mice | |
| Concentrations | 3.0 mg/kg | |
| Incubation Time | 30 and 60 min | |
| Results | In comparison to the vehicle response, there was a significant reduction in glucose solution consumed after the 3.0 mg/kg dose of SB-742457 |
| Molecular Weight | 353.44 |
| Formula | C19H19N3O2S |
| CAS Number | 607742-69-8 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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