Free shipping on all orders over $ 500

SB269652 

Cat. No. M29307

All AbMole products are for research use only, cannot be used for human consumption.

SB269652  Structure

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

SB269652 is an allosteric modulator of the dopamine D2 receptor (D2R). It is a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.

Chemical Information
Molecular Weight 426.55
Formula C27H30N4O
CAS Number 215802-15-6
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Anitha Kopinathan, et al. J Med Chem. Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-(( trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity䲧瘀Ỵ瘁㧀痿羹皘的郘

[2] Ravi Kumar Verma, et al. PLoS Comput Biol. The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors

[3] Mario Rossi, et al. Mol Pharmacol. The First Negative Allosteric Modulator for Dopamine D2 and D3 Receptors, SB269652 May Lead to a New Generation of Antipsychotic Drugs

[4] Jeremy Shonberg, et al. J Med Chem. Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor

[5] J Robert Lane, et al. Nat Chem Biol. A new mechanism of allostery in a G protein-coupled receptor dimer

Related Dopamine Receptor Products
Nepicastat hydrochloride

Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively.
Naxagolide

Naxagolide (Dopazinol) is a very potent and selective D2 agonist.
Alizapride hydrochloride

Alizapride hydrochloride is a dopamine receptor antagonist used for the theropy of nausea and vomiting.
Azaperone

Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic compound with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
Benztropine mesylate

Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM. Benztropine mesylate is a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects. Benztropine mesylate is also an anti-histamine agent and a dopamine re-uptake inhibitor.
  Catalog
Abmole Inhibitor Catalog




Keywords: SB269652  supplier, Dopamine Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.