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SB 228357 is a 5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function. Orally active in vivo.
| Molecular Weight | 431.39 |
| Formula | C22H17F4N3O2 |
| CAS Number | 181629-93-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 43.14 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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