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SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
| Molecular Weight | 266.3 |
| Formula | C15H14N4O |
| CAS Number | 143797-63-1 |
| Solubility (25°C) | DMSO 53 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] A Meneses. Neurobiol Learn Mem. Do serotonin(1-7) receptors modulate short and long-term memory?
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