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Sanguinarine chloride is a inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Sanguinarine chloride also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Sanguinarine chloride blocks cell cycle in the G1 phase; Sanguinarine chloride inhibits cell growth in human prostate carcinoma cells.
| Cell Experiment | |
|---|---|
| Cell lines | HepG2 HCC cells |
| Preparation method | HepG2 cells were treated with different concentrations of sanguinarine (0.5 μM, 1 μM, 2 μM). The HepG2 cells not treated with sanguinarine were seen as controls. The proliferation of HepG2 cells were measured according to the following CCK8 assay. The concentration with the best inhibitory effect on cell viability was selected for subsequent experiments. Equal concentrations of 0.1% DMSO solution were set as control. In each group, 1×10^4 cells were transfected with Lipofectamine 3000. The transfection procedures were in accordance with the kit instruction. |
| Concentrations | 0.5 μM, 1 μM, 2 μM |
| Incubation time | - |
| Animal Experiment | |
|---|---|
| Animal models | Male Sprague-Dawley (SD) rats |
| Formulation | 0.5% CMC-Na |
| Dosages | 40 mg/kg |
| Administration | Oral gavage |
| Molecular Weight | 367.78 |
| Formula | C20H14ClNO4 |
| CAS Number | 5578-73-4 |
| Solubility (25°C) | DMSO 3.8 mg/mL |
| Storage | 2-8°C, dry, protect from light, sealed |
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