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Sanggenon C is a flavanone diels-Alder adduct compound isolated from the root bark of the genus Morus Cathayana. Sanggenon C plays a protective role in cardiac hypertrophy and fibrosis by inhibiting the calcineurin /NFAT2 pathway. Sanggenon C inhibited the expression of inducible nitric oxide synthase, tumor necrosis factor -α -stimulated cell adhesion and vascular cell adhesion molecule-1 in RAW264.7 cells by inhibiting NF-κB activity. Sanggenon C had antioxidant and anti-inflammatory effects, and also inhibited pancreatic lipase (PL) with IC50 of 3.00 μM.
| Molecular Weight | 708.71 |
| Formula | C40H36O12 |
| CAS Number | 80651-76-9 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Related NF-κB Products |
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| QNZ
QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel. |
| Caffeic Acid Phenethyl Ester
Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. |
| Cepharanthine
Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. |
| JSH-23
Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| Methylthiouracil
Methylthiouracil is an anti-thyroid agent. Methylthiouracil inhibits TNF-α and IL-6 production and NF-κB and ERK1/2 activation. |
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