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Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.
| Molecular Weight | 479.81 |
| Formula | C21H17Cl3N4OS |
| CAS Number | 405060-95-9 |
| Solubility (25°C) | DMSO 76 mg/mL |
| Storage | 2-8°C, protect from light |
| Related PERK Products |
|---|
| GSK2606414
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. |
| GSK2656157
GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM, 500-fold greater against a panel of 300 kinases. |
| trans-ISRIB
trans-ISRIB is a integrated stress response (ISR) inhibitor. |
| ISRIB
ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM. |
| CCT020312
CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells. |
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