All AbMole products are for research use only, cannot be used for human consumption.
Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase.Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.Ssd was shown to increase cytosolic calcium level via direct inhibition of sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase pump,leading to autophagy induction through the activation of the Ca(2+)/calmodulin-dependent kinase kinase-AMP-activated protein kinase-mammalian target of rapamycin pathway.Ssd treatment causes the disruption of calcium homeostasis, which induces endoplasmic reticulum stress as well as the unfolded protein responses pathway.Ssd also proved to be a potent cytotoxic agent in apoptosis-defective or apoptosis-resistant mouse embryonic fibroblast cells, which either lack caspases 3, 7 or 8 or had the Bax-Bak double knockout.SSd markedly suppressed phosphorylation of nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) and reversed the APAP-induced increases in the target genes of NF-κB, such as pro-inflammatory cytokine Il6 and Ccl2, and those of STAT3, such as Socs3, Fga, Fgb and Fgg. SSd also enhanced the expression of the anti-inflammatory cytokine Il10 mRNA.
Front Pharmacol. 2021 Feb 16;12:625074.
Saikosaponin D Rescues Deficits in Sexual Behavior and Ameliorates Neurological Dysfunction in Mice Exposed to Chronic Mild Stress
Saikosaponin D purchased from AbMole
 |
Source | Front Pharmacol (2021). Figure 5. Saikosaponin D (Abmole Bioscience, Houston, TX, USA) |
| Method | Administration | |
| Cell Lines | chronic mild stress (CMS) mice | |
| Concentrations | - | |
| Incubation Time | - | |
| Results | Consistent with the abovementioned observation, the expression of the neuronal marker MAP2 was decreased in CMS mice (Figure 5C), whereas MAP2 expression was significantly increased in the MePD of CMS+SSD mice. |
 |
Source | Front Pharmacol (2021). Figure 2. Saikosaponin D (Abmole Bioscience, Houston, TX, USA) |
| Method | Administration | |
| Cell Lines | chronic mild stress (CMS) mice | |
| Concentrations | - | |
| Incubation Time | - | |
| Results | SSD treatment remarkably alleviated the adverse effects of CMS, with a statistically significant increase in the time spent exploring an estrous female mouse than a sexually active male mouse. |
| Molecular Weight | 780.98 |
| Formula | C42H68O13 |
| CAS Number | 20874-52-6 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related COX Products |
|---|
| Firocoxib
Firocoxib is a selective COX-2 inhibitor exhibiting high selectivity to inhibit COX-2. |
| Celecoxib
Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). |
| Nepafenac
Nepafenac is an analgesic selective inhibitor of COX-2. |
| Ampiroxicam
Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory compound. |
| Bromfenac Sodium
Bromfenac is a nonsteroidal anti-inflammatory compound (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
