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Saikosaponin C, the active ingredient in Bupleurum, mainly targets amyloid beta and tau proteins in ALZHEIMER's disease. Saikosaponin C inhibited the release of Aβ1-40 and Aβ1-42, and inhibited abnormal tau phosphorylation, but had no effect on BACE1 activity and expression.
| Molecular Weight | 927.12 |
| Formula | C48H78O17 |
| CAS Number | 20736-08-7 |
| Form | Solid |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Chun Sui, et al. Recent Progress in Saikosaponin Biosynthesis in Bupleurum
[2] Junsong Jiang, et al. Saikosaponin D: A potential therapeutic drug for osteoarthritis
[5] Zhi-An Du, et al. Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice
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