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Saikosaponin B1 is a bioactive ingredient of Bupleurum chinense with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in medulloblastoma (MB) models by targeting SMO to inhibit Hedgehog pathway.
| Molecular Weight | 780.99 |
| Formula | C42H68O13 |
| CAS Number | 58558-08-0 |
| Form | Solid |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Chun Sui, et al. Recent Progress in Saikosaponin Biosynthesis in Bupleurum
[2] Junsong Jiang, et al. Saikosaponin D: A potential therapeutic drug for osteoarthritis
[4] Zhi-An Du, et al. Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice
[5] Heyao Ma, et al. Chemosensitizing Effect of Saikosaponin B on B16F10 Melanoma Cells
| Related Smo Products |
|---|
| GDC-0449 (Vismodegib)
GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively. |
| Purmorphamine
Purmorphamine is a small molecule Hh agonist which activates the hedgehog pathway by directly binding to SMO. |
| BMS-833923
BMS-833923 is an orally bioavailable Smoothened antagonist. |
| Halcinonide
Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent. |
| SANT-1
SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
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