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SAFit1 

Cat. No. M28764

All AbMole products are for research use only, cannot be used for human consumption.

SAFit1  Structure

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Quality Control & Documentation
Biological Activity

SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3 nM.

Chemical Information
Molecular Weight 747.87
Formula C42H53NO11
CAS Number 1643125-32-9
Form Solid
Solubility (25°C) DMSO ≥ 300 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Bhavesh Babulal Gabani, et al. Drug Res (Stuttg). Validated LC-MS/MS Method for Simultaneous Quantitation of SAFit-1 and SAFit-2 in Mice Plasma: Application to a Pharmacokinetic Study

[2] Cherno O Sidibeh, et al. Endocrine. FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes

[3] Steffen Gaali, et al. Nat Chem Biol. Selective inhibitors of the FK506-binding protein 51 by induced fit

Related FKBP (FK506-binding protein) Products
Shield-1

Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD)

SAFit2

SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51) with a Ki value of 6 nM. SAfit2 has been used as a potential agent in the study of major depression, obesity, and chronic pain.

  Catalog
Abmole Inhibitor Catalog




Keywords: SAFit1  supplier, FKBP (FK506-binding protein), inhibitors, activators

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