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S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 (NMDPEF) induces autophagy and inhibits QR2-mediated ROS production.
| Molecular Weight | 374.39 |
| CAS Number | 874484-20-5 |
| Solubility (25°C) | DMSO 19.29 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Gilles Ferry, et al. Chem Biol Interact. Old and new inhibitors of quinone reductase 2
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