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S18-000003 is a potent, effective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of 29 nM. S18-000003 inhibits Th17 cells from naive CD4+T cells. S18-000003 inhibits IL-17 production in the skin of IL-23-treated mice in a dose-dependent manner.
| Molecular Weight | 518.55 |
| Formula | C26H25F3N2O4S |
| CAS Number | 2068119-11-7 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | -20°C, sealed |
| Related ROR Products |
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| Dehydrolithocholic acid
Dehydrolithocholic acid is a bile acid metabolite, which inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM). |
| SR3335
SR3335 (ML-176) is a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. |
| SR1078
SR1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ; increases transcription of RORα target genes; thought to increase p53 stability. |
| SR 1001
SR 1001 is a RORα/γ inverse agonist with Ki values of 172 and 111 nM, respectively. |
| GSK2981278
GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). |
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