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S107 binds RyR1 and enhances the binding affinity of calstabin-1. S107 inhibits Ca leak from the sarcoplasmic reticulum (SR). S107 increases FKBP12 binding to RyR1 in SR vesicles in the presence of reduced glutathione and the NO-donor NOC12, with no effect in the presence of oxidized glutathione. S107 can reverse the harmful effects of redox active species on SR Ca2+ release in skeletal muscle by binding to RyR1 low affinity sites.
| Molecular Weight | 209.31 |
| Formula | C11H15NOS |
| CAS Number | 927871-76-9 |
| Solubility (25°C) | DMSO: ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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