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S0859

Cat. No. M5069

All AbMole products are for research use only, cannot be used for human consumption.

S0859 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 70 In stock
10mg USD 100 In stock
25mg USD 217 In stock
50mg USD 395 In stock
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Quality Control & Documentation
Biological Activity

S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). Na(+)-coupled HCO(3)(-) transporters (NBCs) mediate the transport of bicarbonate ions across cell membranes and are thus ubiquitous regulators of intracellular pH.

Product Citations
Chemical Information
Molecular Weight 530.04
Formula C29H24ClN3O3S
CAS Number 1019331-10-2
Solubility (25°C) 43 mg/ml in CHCL3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ann M Larsen, et al. ChemMedChem. Gram-scale solution-phase synthesis of selective sodium bicarbonate co-transport inhibitor S0859: in vitro efficacy studies in breast cancer cells

[2] F F-T Chen, et al. Br J Pharmacol. S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart

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Keywords: S0859 supplier, Sodium Channel, inhibitors, activators

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