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S- (+)-Rolipram is a less active enantiomer of the PDE4 inhibitor with an EC50 of 1.0 uM. It is an anti-inflammatory drug. Rolipram is being studied as a possible alternative to current antidepressants. Recent studies show that rolipram may have antipsychotic effects. It displays activity 10-fold less than R-rolipram at inhibition of PDE IV. It inhibits antigen-induced contraction of guinea-pig colonic smooth muscle.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Male Hartley guinea pigs |
| Formulation | S-(+)-Rolipram is dissolved in 100% PEG at an appropriate concentration. |
| Dosages | 1 mL/kg |
| Administration | Administered via i.v. |
| Molecular Weight | 275.34 |
| Formula | C16H21NO3 |
| CAS Number | 85416-73-5 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Seyed Mohammad Nabavi, et al. Phosphodiesterase inhibitors say NO to Alzheimer's disease
[4] Kam Leung. 4-(3-Cyclopentoxy-4-[ 11 C]methoxy-phenyl)pyrrolidin-2-one
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