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(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48). (S)-(+)-Dimethindene maleate (2 μM; 1 h) significantly impaires the developmental potency of mouse extended pluripotent stem (mEPS) cells in chimeric blastocysts and leads to rapid differentiation of primed human pluripotent stem cell (hPSC)-converted hEPS cells.
| Molecular Weight | 408.49 |
| Formula | C24H28N2O4 |
| CAS Number | 136152-65-3 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 4°C, dry, sealed |
| Related AChR/AChE Products |
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