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(S)-LY-3381916

Cat. No. M58372

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(S)-LY-3381916 Structure
Synonym:

(S)-IDO1-IN-5

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Quality Control & Documentation
Biological Activity

(S)-LY-3381916 is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

Chemical Information
Molecular Weight 396.45
Formula C23H25FN2O3
CAS Number 2166616-76-6
Form Solid
Solubility (25°C) DMSO 150 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Related IDO Products
IDO-IN-2 (NLG-919 Analogue)

NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.

IDO5L

IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM.

Coptisine

Coptisine, an alkaloid isolated from Coptis, is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM.

Coptisine chloride

Coptisine chloride is an effective and non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. Coptisine chloride is an effective H1N1 neuraminidase (NA-1) inhibitor with IC50 of 104.6 μg/mL, which can be used for influenza A virus (H1N1) infection.

Coptisine-Sulfate

Coptisine Sulfate is an alkaloid isolated from coptis coptidis. It is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: (S)-LY-3381916, (S)-IDO1-IN-5 supplier, IDO, inhibitors, activators

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