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S-Adenosyl-L-methionine disulfate tosylate

Cat. No. M11548

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S-Adenosyl-L-methionine disulfate tosylate Structure
Synonym:

Ademetionine disulfate tosylate; S-Adenosyl methionine disulfate tosylate; AdoMet disulfate tosylate

Size Price Availability Quantity
100mg USD 90 In stock
250mg USD 170 In stock
500mg USD 290 In stock
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Quality Control & Documentation
Biological Activity

S-adenosyl-l-methionine disulfate tosylate (Ademetionine disulfate tosylate) is the main biomethyl donor synthesized in all mammalian cells, but is most abundant in liver. Ademetionine has anti-inflammatory activity and has been used in studies of chronic liver disease.

Chemical Information
Molecular Weight 766.79
Formula C22H34N6O16S4
CAS Number 97540-22-2
Form Solid
Solubility (25°C) DMSO ≥ 50 mg/mL
Water 30 mg/mL
Storage 4°C, protect from light, dry, sealed
References

[1] Jin Yang, et al. Clin Ther. Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: a multiple-dose, open-label, parallel-group study in healthy Chinese volunteers

[2] M Tsuji, et al. Jpn J Pharmacol. Protective effect of S-adenosyl-L-methionine against CCl4-induced hepatotoxicity in cultured hepatocytes

[3] M Tsuji, et al. Jpn J Pharmacol. Protective effects of S-adenosyl-L-methionine against enzyme leakage from cultured hepatocytes and hypotonic hemolysis

[4] G P Bray, et al. Hepatology. S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models

Related Metabolite/Endogenous Metabolite Products
2'-Deoxyinosine

2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability.

Ribitol

Ribitol (Adonitol) is a crystalline pentose alcohol formed by the reduction of ribose.

Glycodeoxycholic Acid

Glycodeoxycholic Acid is an endogenous metabolite. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis.

Glycolithocholic acid

Glycolithocholic acid, an endogenous metabolite, is a glycine conjugated secondary bile acid. Glycolithocholic acid can be used to study ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH0) and primary sclerosing cholangitis (PSC).

4-Aminohippuric Acid

4-Aminohippuric acid is a typical substrate of organic anion transport systems. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow.

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Keywords: S-Adenosyl-L-methionine disulfate tosylate, Ademetionine disulfate tosylate; S-Adenosyl methionine disulfate tosylate; AdoMet disulfate tosylate supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

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