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RYL-552 

Cat. No. M28876

All AbMole products are for research use only, cannot be used for human consumption.

RYL-552  Structure

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Quality Control & Documentation
Biological Activity

RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a P. falciparum NADH dehydrogenase 2 (PfNDH2) inhibtor.

Chemical Information
Molecular Weight 427.39
Formula C24H17F4NO2
CAS Number 1801444-56-3
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tao Xie, et al. Phys Chem Chem Phys. The global motion affecting electron transfer in Plasmodium falciparum type II NADH dehydrogenases: a novel non-competitive mechanism for quinoline ketone derivative inhibitors

[2] Kristin D Lane, et al. Proc Natl Acad Sci U S A. Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors

[3] Yiqing Yang, et al. J Med Chem. Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria

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  Catalog
Abmole Inhibitor Catalog




Keywords: RYL-552  supplier, Mitochondrial Related, inhibitors, activators

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