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Ruzinurad

Cat. No. M45366

All AbMole products are for research use only, cannot be used for human consumption.

Ruzinurad Structure
Synonym:

HR011303; SHR4640

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Quality Control & Documentation
Biological Activity

Ruzinurad is a highly selective URATl inhibitor for hyperuricemia.

Chemical Information
Molecular Weight 338.22
Formula C14H12BrNO2S
CAS Number 1638327-48-6
Form Solid
Solubility (25°C) DMSO 33.33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Beibei Liang, et al. Clin Pharmacol Drug Dev. Effect of Food on the Pharmacokinetics and Pharmacodynamics of a Single Oral Dose of SHR4640, a Selective Urate Transporter 1 Inhibitor, in Healthy Chinese Male Volunteers

[2] Yanwei Lin, et al. Rheumatology (Oxford). Efficacy and safety of a selective URAT1 inhibitor SHR4640 in Chinese subjects with hyperuricaemia: a randomized controlled phase II study

Related URAT1 Products
Lesinurad

Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.

Verinurad

Verinurad, also known as RDEA3170, is an organic anion transporter URAT1 inhibitor with an IC50 of 25 nM.

Dotinurad

Dotinurad is a potent selective urate reabsorption inhibitor. Dotinurad inhibits Urate Transporter 1 (URAT1), IC50 value is 37.2 nM. Dotinurad is used as a uric acid-enhancing excretor.

  Catalog
Abmole Inhibitor Catalog




Keywords: Ruzinurad, HR011303; SHR4640 supplier, URAT1, inhibitors, activators

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