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RUNX1/ETO tetramerization-IN-1 

Cat. No. M30817

All AbMole products are for research use only, cannot be used for human consumption.

RUNX1/ETO tetramerization-IN-1  Structure

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Quality Control & Documentation
Biological Activity

RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor of RUNX1/ETO tetramerization, exhibits anti-leukemic effect. RUNX1/ETO tetramerization-IN-1 specifically targets to NHR2 of RUNX1/ETO (EC50=0.25 μM), restores gene expression down-regulated by RUNX1/ETO. RUNX1/ETO tetramerization-IN-1 inhibits the proliferation of RUNX1/ETO-depending SKNO-1 cells, and reduces the RUNX1/ETO-related tumor growth in a mouse model.

Chemical Information
Molecular Weight 342.3
Formula C18H14O7
CAS Number 88755-39-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Caroline Schoenherr, et al. PLoS One. Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase

[2] Anetta Ptasinska, et al. Cell Rep. RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction

[3] Justin Loke, et al. Cell Rep. RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML

[4] Shan Lin, et al. Adv Exp Med Biol. RUNX1-ETO Leukemia

[5] Kentson Lam, et al. Front Biosci (Landmark Ed). RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis

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Abmole Inhibitor Catalog




Keywords: RUNX1/ETO tetramerization-IN-1  supplier, inhibitors, activators

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