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Ruboxistaurin (LY333531) is an orally active, selective PKC beta inhibitor (Ki=2 nM), ruboxistaurin exhibits ATP-dependent competitive inhibition of PKC beta I, which IC50 4.7 nM. Ruboxistaurin for PKC beta II IC50 5.9 nM.
| Molecular Weight | 468.55 |
| Formula | C28H28N4O3 |
| CAS Number | 169939-94-0 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] No authors listed. Drugs R D. Ruboxistaurin: LY 333531
[5] Christina A Taulien, et al. Drugs Today (Barc). Ruboxistaurin
| Related PKC Products |
|---|
| Enzastaurin
Enzastaurin inhibits PKCβ, PKCα, PKCγ and PKCε with IC50's of 0.006, 0.039, 0.083 and 0.110 µM, respectively. |
| Go 6983
Go 6983 is a fast acting, lipid soluble, broad spectrum protein kinase C inhibitor. |
| Staurosporine
Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. |
| Zoledronic acid
Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects. |
| Dequalinium Chloride
Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM. |
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