Free shipping on all orders over $ 500

Rubone 

Cat. No. M30559

All AbMole products are for research use only, cannot be used for human consumption.

Rubone  Structure

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhanced the anticancer effect of Paclitaxel (PTX) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets.

Chemical Information
Molecular Weight 374.38
Formula C20H22O7
CAS Number 73694-15-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Feng Lin, et al. Biomaterials. Dual responsive micelles capable of modulating miRNA-34a to combat taxane resistance in prostate cancer

[2] Di Wen, et al. Cancer Res. Micellar Delivery of miR-34a Modulator Rubone and Paclitaxel in Resistant Prostate Cancer

[3] Zhangang Xiao, et al. Mol Cell Oncol. Small molecule targeting miR-34a for cancer therapy

[4] Xiongwei Deng, et al. ACS Appl Mater Interfaces. Carboxymethyl Dextran-Stabilized Polyethylenimine-Poly(epsilon-caprolactone) Nanoparticles-Mediated Modulation of MicroRNA-34a Expression via Small-Molecule Modulator for Hepatocellular Carcinoma Therapy

[5] Zhangang Xiao, et al. Cancer Res. A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma

  Catalog
Abmole Inhibitor Catalog




Keywords: Rubone  supplier, MicroRNA (miRNA), inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.