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RS102895 hydrochloride is a cCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). RS102895 hydrochloride blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. RS102895 hydrochloride also inhibits α1A, α1D and 5-HT1A receptors.
| Molecular Weight | 426.86 |
| Formula | C21H21F3N2O2.HCl |
| CAS Number | 1173022-16-6 |
| Solubility (25°C) | DMSO 30 mg/mL (ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CCR Products |
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| Bindarit
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| BMS-813160
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| INCB3284 dimesylate
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